Article Biotechnology & Applied Microbiology
Inactivation Mechanism and Efficacy of Grape Seed Extract for Human Norovirus Surrogate
Chamteut Oh, Ratul Chowdhury, Laxmicharan Samineni, Joanna L. Shisler, Manish Kumar, Thanh H. Nguyen
Summary: Human noroviruses are major food- and waterborne pathogens. Proper sanitation or disinfection is critical to minimize disease caused by human noroviruses. Grape seed extract (GSE) outperforms chemical disinfectants in inactivating Tulane virus, a human norovirus surrogate, by inducing virus aggregation through physical interaction with viral capsid proteins.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2022)
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Article Biotechnology & Applied Microbiology
Grape seed extract against Aichi virus infectivity in model foods and contact surfaces
Snehal S. Joshi, Doris H. D'Souza
Summary: Grape seed extract (GSE) shows promising antiviral potential against Aichi virus (AiV) at low concentrations and short contact times, making it a potential candidate for controlling the spread of this enteric virus.
FOOD MICROBIOLOGY (2021)
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Article Biotechnology & Applied Microbiology
Novel grape seed extract nanoparticles attenuate amikacin-induced nephrotoxicity in rats
Alyaa Farid, Dina Mohamed, Dina Mostafa, Rawan Tarek, Viola Sherif, Gehan Safwat
Summary: This study investigates the effectiveness of grape seed extract nanoparticles in protecting against amikacin-induced kidney injury. The results show that grape seed extract nanoparticles reduce oxidative stress and inflammation, and have a protective effect on the kidneys.
AMB EXPRESS (2023)
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Article Food Science & Technology
Effects of grape seed proanthocyanidin extract on lipopolysaccharide translocation and trafficking from the gut to tissues
Marta Sierra-Cruz, Alba Miguens-Gomez, Esther Rodriguez-Gallego, Claudio D'Addario, Martina Di Bartolomeo, M. Teresa Blay, Montserrat Pinent, Raill Beltran-Debon, Ximena Terra
Summary: Diet-induced changes in the intestinal barrier and gut microbiota lead to the translocation of lipopolysaccharide (LPS) from the lumen to the lamina propria through different mechanisms, resulting in metabolic endotoxemia. The study evaluated the role of grape seed proanthocyanidin extract (GSPE) in modulating LPS translocation and the underlying mechanisms using in vitro and in vivo experiments. GSPE was found to regulate intestinal permeability by modulating receptor-mediated endocytosis and the interaction between gut microbiota and the endocannabinoid system through epigenetic mechanisms. These findings suggest that GSPE can improve intestinal dysfunction and metabolic endotoxemia caused by a high-fat diet.
JOURNAL OF FUNCTIONAL FOODS (2023)
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Article Biochemistry & Molecular Biology
Performance-enhanced regenerated cellulose film by adding grape seed extract
Yu-qing Zhang, Jun Li, Xiao-juan Huang, Cai-xia Yang, Chao Wu, Zai-lei Yang, De-qiang Li
Summary: This study developed an eco-friendly food packaging material using regenerated cellulose films with the addition of grape seed extract (GSE) and polyethylene glycol 200 (PEG). The composite film showed improved mechanical properties, water contact angle, UV-blocking properties, and exhibited color changes under different pH conditions. Furthermore, the addition of GSE delayed the decomposition and biodegradation of strawberries. This research demonstrates the potential of regenerated cellulose film as a color sensor in food packaging.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)
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Article Food Science & Technology
Cocoa Spread with Grape Seed Oil and Encapsulated Grape Seed Extract: Impact on Physical Properties, Sensory Characteristics and Polyphenol Content
Ivana Loncarevic, Jovana Petrovic, Nemanja Teslic, Ivana Nikolic, Nikola Maravic, Biljana Pajin, Branimir Pavlic
Summary: This study aimed to use grape pomace, a by-product of wine production rich in polyphenols, to make enriched cocoa spread. The formulation was modified by substituting refined sunflower oil with cold-pressed grape seed oil. The addition of grape seed extract encapsulated on maltodextrins further increased the polyphenols and flavonoids content. The sensory characteristics of the enriched spreads were positively affected by the encapsulates, reducing the grape seed oil aroma and sweetness.
FOODS (2022)
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Review Biotechnology & Applied Microbiology
Incorporation of grape seed extract towards wound care product development
Amita Ajit, A. G. Vishnu, Prashanth Varkey
Summary: Naturally derived ingredients are increasingly used in therapeutic drug formulations, driven by consumer concerns about chemical side effects. Despite progress in the development of wound care products, there are still limitations in effectively treating impaired healing caused by biofilms, inflammation, and oxidation. The search for improved drug formulations, preferably using natural ingredients, continues to meet the demand for cost-effective solutions to accelerate the wound-healing process.
3 BIOTECH (2021)
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Article Multidisciplinary Sciences
Grape seed proanthocyanidin extract inhibits DNA and protein damage and labile iron, enzyme, and cancer cell activities
Hosam M. Habib, Esmail M. El-Fakharany, E. Kheadr, Wissam H. Ibrahim
Summary: This study demonstrates for the first time that grape seed extract can inhibit DNA and protein damage, as well as labile iron activity, in vitro. Additionally, it also inhibits the activity of certain enzymes and reduces the viability of some cells. These findings further support the potential of grape seed extract in disease prevention and therapy.
SCIENTIFIC REPORTS (2022)
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Article Biochemistry & Molecular Biology
Multifunctional chitosan/grape seed extract/silver nanoparticle composite for food packaging application
Xixi Zhao, Ruofei Tian, Jingyi Zhou, Yanlin Liu
Summary: Food-borne fungi pose significant hazards to food preservation and human health, calling for packaging films with antimicrobial and antioxidant activities. In this study, silver nanoparticles were synthesized from grape seed extracts and coated with chitosan. The results showed that grapes treated with chitosan-coated silver nanoparticles exhibited reduced decay percentage and weight loss, maintained high titratable acidity, and inhibited mold growth during storage.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)
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Article Biochemistry & Molecular Biology
Pre-Treatment with Grape Seed Extract Reduces Inflammatory Response and Oxidative Stress Induced by Helicobacter pylori Infection in Human Gastric Epithelial Cells
Jose Manuel Silvan, Alba Gutierrez-Docio, Esperanza Guerrero-Hurtado, Lucia Domingo-Serrano, Ana Blanco-Suarez, Marin Prodanov, Teresa Alarcon-Cavero, Adolfo J. Martinez-Rodriguez
Summary: H. pylori is a pathogenic bacteria associated with gastritis, gastric ulcers, and gastric cancer. Research shows that grape seed extract and its enriched fractions can reduce inflammatory response and oxidative stress, demonstrating antibacterial activity against H. pylori infection.
ANTIOXIDANTS (2021)
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Article Biochemistry & Molecular Biology
Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a d-galactose-induced aging mouse model by modulating the gut microbiota
Kangliang Sheng, Jian Yang, Yifan Xu, Xiaowei Kong, Jingmin Wang, Yongzhong Wang
Summary: This study evaluated the effect of grape seed proanthocyanidin extract (GSPE) on aging and found that GSPE can improve antioxidant capacity and reduce inflammation levels. The study also discovered that GSPE administration can affect the gut microbiota composition and inhibit the NLRP3 inflammasome signaling pathway, providing a novel strategy for alleviating aging-induced alterations.
FOOD & FUNCTION (2022)
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Article Nutrition & Dietetics
Grape-Seed Proanthocyanidin Extract Reverts Obesity-Related Metabolic Derangements in Aged Female Rats
Marta Sierra-Cruz, Alba Miguens-Gomez, Carme Grau-Bove, Esther Rodriguez-Gallego, Mayte Blay, Montserrat Pinent, Anna Ardevol, Ximena Terra, Raul Beltran-Debon
Summary: Obesity and aging are global concerns, with adaptive homeostasis compromised in the elderly. Grape-seed proanthocyanidin extract (GSPE) may be effective in ameliorating these issues, especially in young animal models. This study confirmed that simultaneous administration of GSPE can improve metabolic disruptions caused by an obesogenic diet in aged rats.
NUTRIENTS (2021)
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Article Agriculture, Dairy & Animal Science
Grape seed extract supplementation in heat-stressed preweaning dairy calves: I. Effects on antioxidant status, inflammatory response, hematological and physiological parameters
Emin Urkmez, Hakan Biricik
Summary: The supplementation of grape seed extract (GSE) improved antioxidant and anti-inflammatory activities, as well as hematological parameters in heat-stressed calves. It also reduced the respiratory rate, alleviating the effects of heat stress.
ANIMAL FEED SCIENCE AND TECHNOLOGY (2022)
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Article Biochemistry & Molecular Biology
Delivery system for grape seed extract based on biodegradable pectin-Zn-alginate gel particles
Elena A. Gunter, Oxana V. Popeyko
Summary: Pectin-Zn-alginate gel particles derived from callus culture pectin demonstrated higher gel strength and encapsulation capacity. Increasing the alginate concentration increased the gel strength of the particles. The grape seed extract (GSE) loaded and empty particles showed swelling behaviors in simulated gastric fluid (SGF) and intestinal fluid (SIF). The release of GSE was influenced by the particle gel strength and swelling degree.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)
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Article Chemistry, Applied
Nano and micro lupin protein-grape seed extract conjugates stabilizing oil-in-water emulsions
Cristhian Rafael Lopes Francisco, Tatiana Porto Santos, Rosiane Lopes Cunha
Summary: Conjugation of lupin protein with grape seed extract improved the stabilization of oil-in-water emulsions. Both nano and micro particles of the conjugates were able to stabilize the emulsions, with micro particles showing better stability and gel-like behavior. The dominant stabilizing mechanism of the conjugates was Pickering-type, but other mechanisms may also be involved.
FOOD HYDROCOLLOIDS (2023)
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Article Biochemistry & Molecular Biology
Pharmacological Potential and Chemical Composition of Crocus sativus Leaf Extracts
Olha Mykhailenko, Vilma Petrikaite, Michal Korinek, Fang-Rong Chang, Mohamed El-Shazly, Chia-Hung Yen, Ivan Bezruk, Bing-Hung Chen, Chung-Fan Hsieh, Dmytro Lytkin, Liudas Ivanauskas, Victoriya Georgiyants, Tsong-Long Hwang
Summary: This study aimed to determine the chemical composition of Crocus leaves and evaluate their cytotoxic activity against cancer cells. The results showed that the ethanol extract of Crocus leaves exhibited higher cytotoxicity against melanoma and triple-negative breast cancer cells compared to the aqueous extract. The major active ingredients in the leaf extracts were mangiferin and isoorientin. Kaempferol and quercetin were identified as the most active compounds.
MOLECULES (2022)
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Article Biochemistry & Molecular Biology
Physapruin A Induces Reactive Oxygen Species to Trigger Cytoprotective Autophagy of Breast Cancer Cells
Tzu-Jung Yu, Jun-Ping Shiau, Jen-Yang Tang, Chia-Hung Yen, Ming-Feng Hou, Yuan-Bin Cheng, Chih-Wen Shu, Hsueh-Wei Chang
Summary: The study demonstrates that PHA can induce autophagy in breast cancer cells, and autophagy inhibitors can enhance the cytotoxic effects of PHA. Furthermore, PHA increases ROS levels, while ROS scavenger NAC decreases PHA-induced autophagy activity. Autophagy inhibitors also enhance PHA-induced apoptosis, while NAC blocks apoptosis. This suggests that autophagy induced by PHA plays an antioxidant and anti-apoptotic role in breast cancer cells.
ANTIOXIDANTS (2022)
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Article Biochemistry & Molecular Biology
Emodin Ameliorates the Efficacy of Carfilzomib in Multiple Myeloma Cells via Apoptosis and Autophagy
Chin-Mu Hsu, Chia-Hung Yen, Shu-Chen Wang, Yi-Chang Liu, Chien-Tzu Huang, Min-Hong Wang, Tzer-Ming Chuang, Ya-Lun Ke, Tsung-Jang Yeh, Yuh-Ching Gau, Jeng-Shiun Du, Hui-Ching Wang, Shih-Feng Cho, Yuhsin Tsai, Chi-En Hsiao, Samuel Yien Hsiao, Hui-Hua Hsiao
Summary: The combination of carfilzomib and emodin synergistically inhibits the proliferation and viability of multiple myeloma cells by inducing apoptosis and autophagy pathways. This provides a potential molecular target for combination therapy in multiple myeloma patients.
BIOMEDICINES (2022)
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Article Chemistry, Medicinal
Antibladder Cancer Effects of Excavatolide C by Inducing Oxidative Stress, Apoptosis, and DNA Damage In Vitro
Che-Wei Yang, Tsu-Ming Chien, Chia-Hung Yen, Wen-Jeng Wu, Jyh-Horng Sheu, Hsueh-Wei Chang
Summary: This study investigated the inhibitory effects of Excavatolide C (EXCC) from Briareum excavatum on bladder cancer cell proliferation, and its association with oxidative stress. The results showed that EXCC can inhibit the proliferation of bladder cancer cells by increasing cellular and mitochondrial oxidative stresses, and this effect can be reversed by N-acetylcysteine (NAC).
PHARMACEUTICALS (2022)
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Article Pharmacology & Pharmacy
Sulforaphane suppresses dengue virus replication by inhibition of dengue protease and enhancement of antiviral interferon response through Nrf2-mediated heme oxygenase-1 induction
Wei -Chun Chen, Chung-Hao Huang, Wangta Liu, Jin-Ching Lee
Summary: Dengue virus (DENV) infection is a life-threatening disease with no effective treatment options. However, a study found that sulforaphane (SFN) has significant antiviral activity against DENV by inducing heme oxygenase-1 (HO-1) expression and inhibiting viral protease activity. This suggests that SFN could be a promising candidate for treating DENV.
ANTIVIRAL RESEARCH (2022)
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Article Biochemistry & Molecular Biology
Methanol Extract of Commelina Plant Inhibits Oral Cancer Cell Proliferation
Wangta Liu, Yin-Yin Hsu, Jen-Yang Tang, Yuan-Bin Cheng, Ya-Ting Chuang, Jiiang-Huei Jeng, Chia-Hung Yen, Hsueh-Wei Chang
Summary: This study found that the crude extract of Commelina plants, MECO, has antiproliferation and apoptosis-inducing effects on oral cancer cells, with minimal effects on normal cells. These selective effects may be associated with oxidative stress in oral cancer cells.
ANTIOXIDANTS (2022)
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Article Biochemistry & Molecular Biology
Prinsepiae Nux Extract Activates NRF2 Activity and Protects UVB-Induced Damage in Keratinocyte
Shih-Han Wang, Yi-Siao Chen, Kuei-Hung Lai, Chung-Kuang Lu, Hsun-Shuo Chang, Ho-Cheng Wu, Feng-Lin Yen, Lo-Yun Chen, Jin-Ching Lee, Chia-Hung Yen
Summary: The extract of Prinsepiae Nux was identified as a potent NRF2 activator and showed potential in preventing UVB-induced skin damage.
ANTIOXIDANTS (2022)
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Article Chemistry, Medicinal
Novel Aporphine- and Proaporphine-Clerodane Hybrids Identified from the Barks of Taiwanese Polyalthia longifolia (Sonn.) Thwaites var. pendula with Strong Anti-DENV2 Activity
I-Wen Lo, Geng-You Liao, Jin-Ching Lee, Chi- Chang, Yang-Chang Wu, Yen-Yu Chen, Shang-Pin Liu, Huey-Jen Su, Chih- Liu, Chia-Yi Kuo, Zheng-Yu Lin, Tsung-Lin Li, Yun-Sheng Lin, Chia-Ching Liaw
Summary: Hybrid natural products produced through mixed biosynthetic pathways have complex structures and diverse medicinal properties. This study reports the discovery of four structurally attractive diterpene-alkaloid conjugates from the barks of Taiwanese Polyalthia longifolia, which exhibit promising anti-DENV2 activity. In vitro experiments and molecular docking analysis suggest that these compounds are novel and effective DENV NS2B-NS3 protease inhibitors.
PHARMACEUTICALS (2022)
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Article Biochemistry & Molecular Biology
New 3,4-seco-3,19-Dinor- and Spongian-Based Diterpenoid Lactones from the Marine Sponge Spongia sp.
Chi-Jen Tai, Chih-Hua Chao, Atallah F. Ahmed, Chia-Hung Yen, Tsong-Long Hwang, Fang-Rong Chang, Yusheng M. Huang, Jyh-Horng Sheu
Summary: Chemical investigation of the Red Sea sponge Spongia sp. resulted in the discovery of four new compounds, secodinorspongins A-D (1-4), as well as a known compound sponginolide (5). The structures of these compounds and their absolute configurations were elucidated using spectroscopic methods and a comparison of calculated and experimental CD spectra. A possible biosynthetic pathway for compounds 1-4 was proposed. The cytotoxic, antibacterial, and anti-inflammatory activities of compounds 1-5 were also evaluated, with compound 1 showing inhibitory activity against Staphylococcus aureus growth, and compounds 4 and 5 suppressing superoxide-anion generation and elastase release in human neutrophils.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
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Article Agriculture, Multidisciplinary
Chemical Constituents and Bioactive Principles from the Mexican Truffle and Fermented Products of the Derived Fungus Ustilago maydis MZ496986
Ho-Cheng Wu, Hsiao-Yang His, George Hsiao, Chia-Hung Yen, Jyh-Yih Leu, Chin-Chung Wu, Szu-Hsing Chang, Shu-Jung Huang, Tzong-Huei Lee
Summary: This study examined the phytochemical and pharmacological properties of corn galls and the fermentate of Ustilago maydis MZ496986. It identified six new chemical entities and 17 known components. Compounds 3, 5, and 9 showed potent inhibitory activities against nitric oxide production, and compound 9 also attenuated NF-KB activation. Ustilagol G exhibited potent antiplatelet aggregation. These findings suggest that corn galls and Ustilago maydis MZ496986 fermentate have potential as functional foods for improving inflammation-related discomforts and vascular obstruction.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)
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Article Biochemistry & Molecular Biology
Physapruin A Exerts Endoplasmic Reticulum Stress to Trigger Breast Cancer Cell Apoptosis via Oxidative Stress
Tzu-Jung Yu, Jun-Ping Shiau, Jen-Yang Tang, Ammad Ahmad Farooqi, Yuan-Bin Cheng, Ming-Feng Hou, Chia-Hung Yen, Hsueh-Wei Chang
Summary: Physapruin A (PHA), a compound extracted from Physalis plants, can induce endoplasmic reticulum stress to regulate proliferation and apoptosis of breast cancer cells, which is associated with oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
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Article Medicine, General & Internal
The Expression and Prognostic Value of Cancer Stem Cell Markers, NRF2, and Its Target Genes in TAE/TACE-Treated Hepatocellular Carcinoma
Duurenjargal Tseeleesuren, Hui-Hua Hsiao, Rajni Kant, Yu-Chuen Huang, Hung-Pin Tu, Chih-Chung Lai, Shiu-Feng Huang, Chia-Hung Yen
Summary: The study found that CD133 overexpression was associated with poor survival in HCC patients, while NRF2 and its signaling components were not correlated with survival. Combination marker analysis indicated that co-expression of NQO1 and CD133 was associated with poor outcome in TAE/TACE-treated HCC patients.
MEDICINA-LITHUANIA (2022)
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